Configure Protégé

Additionally, to work with large ontologies such as SNOMED, you have to set up a heap size parameter for Protege. Just click a right button on and choose "show package contents".

protege show content

Now you are able to find Info.plist file. Open it in your favourite text editor and specify parameters Xms, Xmx and make sure DentityExpansionLimit is equal to 800000000. Set up Xmx as much as you can.